Scientists Discover a Combination for Cleansing Brain Plaque

In a groundbreaking discovery, researchers from the University of California, Irvine have found a potential new path towards treating age-related cognitive decline and Alzheimer's disease. Their study, published in GeroScience, suggests that supplementing the brain's energy systems with nicotinamide (a form of vitamin B3) and epigallocatechin gallate (a green tea antioxidant) could be the key.

Every cell in the body depends on mitochondria for energy. These power-generating organelles are particularly crucial for brain cells, often referred to as neurons. As we age, mitochondria wear out, leaving cells unable to create the energy they need to function properly. This lack of energy is thought to be a major contributor to aging in the brain.

In the study, the researchers found that a combination of nicotinamide and epigallocatechin gallate can restore brain energy levels in aged neurons to those typically seen in younger cells in just 24 hours. This revival of brain energy levels triggers improved energy metabolism and efficient clearance of amyloid beta aggregates, hallmarks of Alzheimer's disease.

Amyloid proteins accumulate in the brain as we age, leading to memory problems and cognitive decline. The brain has a natural system that removes these proteins, but it requires energy to function. With declining levels of energy, this system becomes less effective, leading to a buildup of amyloid proteins.

Researchers are also working on reinstating youthful levels of guanosine triphosphate (GTP) in the brain. GTP is an essential energy molecule for mitochondria, the brain's energy hubs. Declining levels of GTP contribute to the buildup of amyloid proteins in the brain.

Limiting oxidative stress, a type of damage that occurs when the body produces reactive oxygen species, can reduce the damage typically caused by beta-amyloid. Restoring brain energy levels reduces oxidative stress, further supporting the potential of this treatment.

However, more work is needed to find the best way to administer this treatment. Oral nicotinamide was not very effective in a recent clinical trial due to inactivation in the bloodstream. Further research is necessary to determine the most effective method of delivery.

While this discovery is promising, it's important to note that more research is needed before any treatments based on this finding can be developed. For those interested in learning more about hormonal health and its impact on chronic diseases, the book The Insulin Factor: How to Repair Your Body's Master Controller and Conquer Chronic Disease! may provide valuable insights.

In conclusion, the discovery of a combination of two natural compounds that can restore energy levels in the brains of aging bodies offers a potential new approach to treating age-related cognitive decline and Alzheimer's disease. By understanding and supporting the power-generating mitochondria in the body, it may be possible to start slowing down the effects of aging on the brain today.