Interactions of Ofev: Other medications, alcohol, and further substances to be aware of
Ofev, a medication used to treat lung conditions involving fibrosis (scarring), such as idiopathic pulmonary fibrosis, chronic interstitial lung disease (ILD), and ILD related to systemic sclerosis, comes with a variety of potential interactions and precautions.
If your doctor prescribes Ofev with an NSAID, they'll likely monitor you for GI perforation, a potential side effect. This risk may be increased if you have a history of diverticular disease or have recently had surgery in your abdomen.
Taking Ofev with nonsteroidal anti-inflammatory drugs (NSAIDs), such as ibuprofen or naproxen, may increase the risk of tears in the digestive system. It's important to discuss with your doctor before combining Ofev with NSAIDs.
Ofev is not safe to take while pregnant, and it's unknown whether it's safe to take while breastfeeding. If you have a liver or kidney problem, taking Ofev could worsen these conditions.
Smoking can lower the level of Ofev in your body, making it less effective at treating your lung condition and increasing your risk of a heart attack or stroke.
Certain medications, such as anticoagulants, immunosuppressants, other antifibrotic agents, and drugs affecting liver enzymes, can interact with Ofev. Specific interactions are not extensively detailed, but they should be considered due to Ofev’s metabolism and side effect profile.
Taking Ofev with certain HIV drugs, such as cobicistat or lopinavir/ritonavir, can increase the risk of Ofev's side effects. Similarly, taking Ofev with certain antifungals, such as itraconazole or ketoconazole, can also increase the risk of side effects.
Interactions with other substances, such as alcohol, cannabis, St. John's wort, grapefruit, and certain vitamins, should also be discussed with your doctor or pharmacist. While there are no specific reports of vitamins interacting with Ofev, it's always best to err on the side of caution.
If you have heart disease, you may have an increased risk of blood clots that can lead to a heart attack or stroke while taking Ofev. It's also important to note that Ofev can raise your risk of bleeding, and if you already have blood clotting problems, you may have a higher risk of bleeding when taking Ofev.
In case of any questions about taking Ofev with an NSAID or any other potential interactions, it's recommended to consult your doctor or pharmacist. Symptoms of GI perforation, a potential serious side effect, can include severe abdominal pain, abdominal swelling, nausea and vomiting, fever, and chills.
By being aware of these interactions and precautions, you can help ensure a safer and more effective treatment course with Ofev. Always discuss any concerns with your healthcare provider.
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