Innovative approach aimed at deterrence of breast cancer recurrence

Breast cancer survivors who have experienced a relapse may face an incurable disease, as continuous and indefinite treatment is currently the only option, but it cannot eliminate the cancer completely. A groundbreaking study, led by scientists from the Abramson Cancer Center and Penn's Perelman School of Medicine, has uncovered a promising approach to potentially prevent breast cancer relapses.

The research, published in Nature Medicine, builds on previous findings that showed how dormant tumor cells continue to lay in wait in some patients after breast cancer treatment. Until now, there has not been a way to identify these dormant cells in real time.

Lewis Chodosh, chair of cancer biology and senior author of the study, previously led research to identify the pathways that allow dormant tumor cells to survive in patients for decades. His latest work shows that the sleeper phase of dormant tumor cells presents an opportunity to intervene and eradicate the cells before they return as aggressive, metastatic disease.

The study reveals that certain drugs, which are ineffective against actively growing cancers, have been found to be effective against dormant tumor cells. This significant difference in the biology of dormant and active cancer cells could pave the way for new treatment strategies.

The clinical trial, funded by federal funds, which demonstrated the identification of dormant breast cancer cells associated with increased recurrence risk and their treatment with repurposed drugs, was led by Dr. Filippo Giancotti. This trial offers hope for breast cancer survivors, as it suggests that interventions targeting dormant tumor cells could potentially prevent breast cancer relapses.

It's important to note that breast cancer relapses, or returns after initial treatment, are still incurable. However, this new research offers a glimmer of hope for those affected by this disease. Dormant cancer cells do not show up on standard imaging tests used to watch for breast cancer recurrence, making them a formidable challenge. But with continued research and advancements in technology, the future looks brighter for those battling breast cancer.

In conclusion, this study marks a significant step forward in the fight against breast cancer. By identifying and targeting dormant cancer cells, researchers are one step closer to preventing breast cancer relapses and improving the lives of those affected by this disease.