Enhance the LNP (Lipid Nanoparticle) formula, assessment, and examination using highly effective tools

In a recent webinar, key industry professionals gathered to discuss the latest advancements in lipid nanoparticle (LNP) production, screening, and characterization. The event, which featured a live Q&A session, was produced with support from various unmentioned sources and brought together experts from the fields of engineering and product management.

The panelists for the broadcast included Thibaut Ben Chimol, an Assistant Engineer at Sartorius Polyplus, and Kevin Lance, the Director of Product Management at Unchained Labs. The discussion focused on optimized LNP formulations tailored for specific cell types, such as primary T cells, and the use of advanced tools and methodologies for LNP research and formulation development.

One of the key companies behind these technological innovations is ABITEC Corporation, known for its expertise in lipid chemistry and formulation technologies supporting pharmaceutical applications. Other companies involved in the development of lipid mixtures, like MC3, SM-102, and ALC-0315, are crucial components in mRNA delivery systems.

These formulations are characterized and optimized through various methods, including hydrodynamic diameter measurements, cryo-TEM imaging, and functional screening in cell lines. The webinar highlighted the use of these technologies and screened LNP formulations to discuss efficiency enhancements via lipid composition variations and peptide conjugation strategies to improve delivery, such as targeting brain delivery and optimizing cellular uptake.

One such tool used for precise characterization of particle size and encapsulation efficiency in LNP research is the Stunner AF from Unchained Labs. The webinar also featured the Sunscreen high-throughput screening (HTS) equipment from Unchained Labs and the LipidBrick library from Sartorius Polyplus.

Moreover, the Incucyte Live-Cell Imaging System from Sartorius was showcased for in vitro screening of LNP functionality across various cell lines and immune cells. This system allows for real-time monitoring of cellular responses to LNP formulations, providing valuable insights into their effectiveness and potential applications.

The webinar concluded with a live Q&A session, where attendees had the opportunity to engage with the expert panelists and gain a deeper understanding of the latest developments in LNP technology. Stay tuned for future updates on this exciting field!

Enhance the LNP (Lipid Nanoparticle) formula, assessment, and examination using highly effective tools