Deadly fungal infections pose a worrying silent threat, with scientists issuing urgent warnings about their escalating impact

In a world grappling with the crisis of antibiotic resistance, causing nearly 5 million deaths annually, a new threat is emerging. Fungal infections, which currently affect 6.5 million people and result in 3.8 million deaths each year, are evolving beyond the reach of current medical treatments, creating a "silent pandemic."

At the United Nations conference in September in New York City, researchers are urging for the focus on antibiotic resistance to be expanded to include fungal infections and resistance to antifungal medications. Molecular biologist Norman van Rhijn from the University of Manchester is leading this call, urging governments and the pharmaceutical industry to broaden their focus beyond bacteria.

Preventive measures can significantly reduce the risk of fungal infections. Good hygiene practices, such as keeping skin dry after washing, avoiding sharing personal items, and wearing breathable clothing, are essential. Using antifungal powders in shoes or on feet can also help prevent fungal infections.

For more extensive fungal infections, oral medications like itraconazole and terbinafine may be prescribed. In severe cases, especially in immunocompromised patients, intravenous treatment may be necessary. Common over-the-counter antifungal creams and lotions for fungal skin infections include clotrimazole (Canesten), miconazole (Daktacort, Daktarin), and terbinafine (Lamisil).

Hydrogen peroxide, a common household disinfectant, can kill fungi on contact and is often used for cleaning surfaces. It acts as a strong oxidizing agent, breaking down the cellular structure of fungi upon contact. In a diluted solution, vinegar can also be effective against certain types of fungi, particularly in household cleaning.

A new antifungal agent, occidiofungin, developed by Sano Chemicals, is proving to be a promising solution. It rapidly induces apoptotic cell death in fungi without harming beneficial bacteria. It is effective against various Candida species, including resistant strains like C. auris.

Elderly and immunocompromised individuals are particularly vulnerable to fungal infections. Utilizing effective antifungal agents and adhering to preventive measures can significantly reduce the risk of fungal infections. The World Health Organization released the Fungal Priority Pathogen List in 2022, highlighting dangerous pathogens such as Aspergillus fumigatus, Candida, Nakaseomyces glabratus, and Trichophyton indotineae.

As the world continues to grapple with the challenges of antibiotic resistance, the growing concern of fungal infections cannot be ignored. The UN conference in September presents an opportunity to address this silent pandemic and work towards a future where effective treatments and preventive measures are in place to combat these infections.

Deadly fungal infections pose a worrying silent threat, with scientists issuing urgent warnings about their escalating impact